P3745Facilitating cardiac fibroblast to myofibroblast transformation in 3D peptide hydrogel scaffold culture system
نویسندگان
چکیده
منابع مشابه
Substratum topography modulates corneal fibroblast to myofibroblast transformation.
PURPOSE The transition of corneal fibroblasts to the myofibroblast phenotype is known to be important in wound healing. The purpose of this study was to determine the effect of topographic cues on TGFβ-induced myofibroblast transformation of corneal cells. METHODS Rabbit corneal fibroblasts were cultured on nanopatterned surfaces having topographic features of varying sizes. Cells were cultur...
متن کامل3d Cell Culture Using Monodisperse Peptide Hydrogel Beads
We describe a three-dimensional (3D) cell culture system using monodisperse peptide hydrogel beads. We utilized a self-assembling peptide hydrogel to provide cells in vivo-like microenvironment. We succeeded in encapsulating endothelial cells within the hydrogels by using a 3D microfluidic axisymmetric flow-focusing device (AFFD), and showed the encapsulated endothelial cells were viable and we...
متن کاملInhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol.
Cardiac fibroblasts (CFs) regulate myocardial remodeling by proliferating, differentiating, and secreting extracellular matrix proteins. Prolonged activation of CFs leads to cardiac fibrosis and reduced myocardial contractile function. Resveratrol (RES) exhibits a number of cardioprotective properties; however, the possibility that this compound affects CF function has not been considered. The ...
متن کاملThe mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel.
The aim of this present study was to provide a scaffold as a tool for the investigation of the effect of mechanical stimulation on three-dimensionally cultured cells. For this purpose, we developed an artificial self-assembling peptide (SPG-178) hydrogel scaffold. The structural properties of the SPG-178 peptide were confirmed by attenuated total reflection-Fourier transform infrared spectrosco...
متن کاملInjectable 3D hydrogel scaffold with tailorable porosity post-implantation.
Since rates of tissue growth vary significantly between tissue types, and also between individuals due to differences in age, dietary intake, and lifestyle-related factors, engineering a scaffold system that is appropriate for personalized tissue engineering remains a significant challenge. In this study, a gelatin-hydroxyphenylpropionic acid/carboxylmethylcellulose-tyramine (Gtn-HPA/CMC-Tyr) p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Heart Journal
سال: 2018
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehy563.p3745